Your Journey
IVF pregnancies have a slightly higher miscarriage risk, mainly due to age and chromosomal factors, not your actions. Learn what PGT-A, thrombophilia testing & progesterone support can do.
A positive pregnancy test after IVF is a moment of intense joy — and often intense anxiety. After everything you've been through, the fear of miscarriage is real and understandable. Here's what the evidence shows, and what can be done to support a healthy IVF pregnancy.
IVF pregnancies carry a slightly higher miscarriage rate than naturally conceived pregnancies, approximately 20–25% compared to 15–20% in the general population. This is primarily because women undergoing IVF tend to be older (age is the biggest risk factor for miscarriage), and because IVF allows pregnancies to be confirmed at very early stages, including some that would have been undetected in natural conception.
Chromosomal abnormalities in the embryo are responsible for the majority of first-trimester miscarriages around 50–60%. This is not caused by anything the mother did or didn't do. Preimplantation genetic testing (PGT-A) can screen embryos before transfer, reducing chromosomal miscarriage risk significantly. Dr. Rajesh Modi at Modi Pluro, Nagpur, discusses PGT-A with patients who have had recurrent miscarriage or repeated IVF failure.
Other contributing factors include uterine abnormalities, blood clotting disorders, and immune issues, all of which can be investigated and treated. Progesterone support in the luteal phase (which all IVF patients receive) is a key protective measure. Maintaining healthy lifestyle habits — avoiding smoking, limiting caffeine, managing stress, all contribute to the best possible environment for a developing pregnancy.
Most importantly: each miscarriage is not a reflection of you as a person, or of your fertility treatment team's skill. Miscarriage is a medical event, not a failure. With the right investigation and support at Modi Pluro, most couples who have experienced miscarriage go on to have successful pregnancies.
Q: Should I have PGT-A if I've had recurrent miscarriages?
A: PGT-A is strongly recommended for patients with two or more miscarriages and a history of IVF. Testing embryos before transfer can identify chromosomally normal embryos, significantly reducing the miscarriage rate per transfer. Dr. Modi will assess whether PGT-A is appropriate for your situation.
Q: Is bed rest after embryo transfer recommended?
A: No. Bed rest is not evidence-based and may actually be counterproductive. Light normal activity is fine. Avoid strenuous exercise, heavy lifting, and sexual intercourse during the luteal phase as a precaution.
Q: What investigations should I have after a miscarriage?
A: After one miscarriage, observation is usually recommended. After two or more, a thorough investigation is warranted including chromosomal karyotyping of both partners, thrombophilia screening, immunological testing, uterine assessment via hysteroscopy, and hormonal profile. Dr. Modi follows a structured recurrent miscarriage protocol.
PGT-A is strongly recommended for patients with two or more miscarriages and a history of IVF. Testing embryos before transfer can identify chromosomally normal embryos, significantly reducing the miscarriage rate per transfer. Dr. Modi will assess whether PGT-A is appropriate for your situation.
No. Bed rest is not evidence-based and may actually be counterproductive. Light normal activity is fine. Avoid strenuous exercise, heavy lifting, and sexual intercourse during the luteal phase as a precaution.
After one miscarriage, observation is usually recommended. After two or more, a thorough investigation is warranted including chromosomal karyotyping of both partners, thrombophilia screening, immunological testing, uterine assessment via hysteroscopy, and hormonal profile. Dr. Modi follows a structured recurrent miscarriage protocol.
